If you like Twitter, you may benefit from a more powerful interface. Some solve this through use of TweetDeck, a desktop application that shows multiple Twitter streams (your stream, replies to you, direct messages, etc.) in columns.
The new service PeopleBrowsr is a web-based application that works like TweetDeck. You enter your Twitter account information, and PeopleBrowsr displays columns of streams. You can easily add more streams, and re-arrange them, right in your browser. The interface is a little busy but highly functional, and provides a lot of information at once. Even better, it’s written almost entirely in JavaScript, so it doesn’t depend on heavyweight frameworks like Flash.
Why use this instead of TweetDeck? Because you can use PeopleBrowsr from any computer, anywhere. It goes with you; if you have ‘net access, you can use PeopleBrowsr and manage a huge array of Twitter conversations.
Very, very handy.