If you like Twitter, you may benefit from a more powerful interface. Some solve this through use of TweetDeck, a desktop application that shows multiple Twitter streams (your stream, replies to you, direct messages, etc.) in columns.
Why use this instead of TweetDeck? Because you can use PeopleBrowsr from any computer, anywhere. It goes with you; if you have ‘net access, you can use PeopleBrowsr and manage a huge array of Twitter conversations.
Very, very handy.